04/28/2026
You optimized your portfolio, your team, your lifestyle and your doctor just put you on a drug that’s quietly destroying your most valuable asset. Your body.
Up to 40% of the weight lost on GLP-1s is muscle , not fat. And Mounjaro specifically has been linked to a 10.9% reduction in muscle mass , the equivalent of 5 years of aging in just 72 weeks.
No training. No protein. No muscle.
And when you stop the drug? Your metabolism has nothing left to run on.
Muscle isn’t just about looking good, it stabilizes blood sugar, protects your bones and joints, boosts immunity, and is the #1 driver of your metabolism and longevity.
The research is clear: combining resistance training 3-5x per week with 1.2-2g of protein per kg of bodyweight daily is what protects your lean tissue while on these compounds.
The drug is a tool. The gym and your plate are the strategy.
If you’re on a GLP-1 right now and not training , we need to talk. DM me.
Sources:
• PMC / NIH Effects of GLP-1 Agonists on Musculoskeletal Health (2025)
• American Diabetes Association Muscle Loss & GLP-1 Drugs (2025)
• Look et al. (2025) Mounjaro & Lean Mass Reduction over 72 weeks
• Mass General Hospital Preserving Lean Body Mass on GLP-1 Therapy (2025)
• Barbell Medicine GLP-1 Muscle Loss Evidence Review (2026)