04/07/2021
Supplement Quick Review: Arginine
Arginine is a pre-workout supplement that claims to increase blood flow and oxygen uptake to muscle resulting in increased athletic/exercise performance. What does the research say about its effectiveness?
I analyzed two meta-analysis which collectively examined 26 studies. Overall, the number of quality studies is limited, but the research does seem to suggest it could potentially increase maximal oxygen uptake and performance for both anaerobic and aerobic activities.
This might convince you arginine is worth using, but there are caveats. One of the meta-analyses found that a dose around 10 – 11 grams was required. Single doses this high can potentially cause abdominal distress and leads to a tingling sensation which many may find uncomfortable. Smaller doses spread out through the day were shown to be effective without side effects, but this needs to be done daily to get the performance boost.
It would also seem that the supplement citrulline is actually more effective for increasing arginine levels than pure arginine. Citrulline has a stronger evidence base for being an effective performance supplement especially when compared to arginine.
I was curious if there is a synergistic effect between arginine and citrulline, so I examined two meta-analyses covering this. Unfortunately, the research is very limited. Initial evidence suggests they might work well together, but it is unclear what the effective dose of both are besides the fact that a ratio of 2:1 citrulline to arginine seems to be best.
Final Conclusion: Arginine seems useless unless taken in larger doses and if you aren't already supplementing with citrulline. Arginine and citrulline may work well together, but there isn't enough evidence to justify using it in this way.