Your healthy body

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Most but not all healthy and cancerous proliferating cells take up more glucose as well as synthesise more lactate in th...
20/01/2023

Most but not all healthy and cancerous proliferating cells take up more glucose as well as synthesise more lactate in the presence of oxygen than non-proliferating cells [4, 5]. Otto Warburg hypothesised that this was because of a mitochondrial defect causing cancer cells to rely on glycolysis for ATP resynthesis [6]. However, many cancers have functioning mitochondria [7] and thus a defective oxidative phosphorylation does not generally explain increased glycolytic flux in cancer.

In this review, we first discuss the Warburg effect in cancer and how it helps to provide substrates for anabolism and f...
20/01/2023

In this review, we first discuss the Warburg effect in cancer and how it helps to provide substrates for anabolism and for the generation of biomass. We then review evidence that hypertrophying muscles reprogramme their metabolism similarly to cancer cells. Third, we discuss the potential benefits of such metabolic reprogramming for the prevention and treatment of type 2 diabetes mellitus and obesity.

20/01/2023

Український біатлоніст Дмитро Грущак посів друге місце в гонці переслідування на Універсіаді-2023: як виступи українці, результати гонки, що про це відомо

20/01/2023

Три українські тенісистки Ангеліна Калініна, Марта Костюк та Катерина Байндль зіграли матчі третього кола на Australian Open-2023: результати матчів та що означають їхні ре...

In contrast to sprinting, in events that are highly aerobic, such as the 10,000 m and marathon, performance mainly depen...
18/01/2023

In contrast to sprinting, in events that are highly aerobic, such as the 10,000 m and marathon, performance mainly depends on the rate of metabolic energy consumption, i.e., running economy. Various footwear properties such as mass, cushioning, and longitudinal bending stiffness have repeatedly been shown to affect running economy [23,24,25,26,27,28]. Other factors determining distance running performance include maximum oxygen uptake (V˙O2max
), the fraction of V˙O2max
that can be sustained throughout the duration of the race [29], and the finite amount of energy that can be expended above critical speed (i.e., the anaerobic work capacity) [30], but these seem independent of footwear.

18/01/2023

Мілан та Інтер розіграли Суперкубок Італії-2022. Звіт про матч читайте на Спорт 24.

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