19/09/2026
Two people can follow the same weight-loss diet… but their bodies can respond differently. And genetics is one reason why. 🧬
Ever wondered why the exact same diet works differently for different people? 👀
In the “Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion” research, researchers followed 609 overweight adults for 12 months while comparing a healthy low-fat diet with a healthy low-carbohydrate diet.
They also looked at whether genetic differences or insulin secretion could explain why some people lost more weight than others.
Interestingly, researchers did not find a significant interaction between genotype pattern and diet type for weight loss. In other words, this study did not show that having a particular genetic pattern made one of the two diets clearly better for weight loss.
But the study still highlights an important point:
🧬 People can respond differently to the same diet.
Genetics is one possible contributor, along with:
🍽️ Food intake
🏃 Activity levels
💪 Body composition
😴 Sleep and recovery
🦠 Gut and metabolic differences
📉 How consistently someone follows the diet
So your friend losing more weight on the same diet doesn’t necessarily mean you’re doing something wrong.
The takeaway?
There isn’t always one perfect weight-loss diet that works identically for everyone.
What matters is finding an approach that helps you maintain a sustainable calorie deficit while eating nutritious foods and staying consistent. 💪
💬 Have you ever tried the same diet as someone else and got completely different results? Comment “YES” below! 👇
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Research: Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion
Authors: Christopher D. Gardner et al.
Journal: JAMA, 2018;319(7):667–679
PMID: 29466592
DOI: 10.1001/jama.2018.0245