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10/03/2022

Sport is good for the body and for the mind, that’s why it has been practiced since ancient times for its benefits. There are, however, some sports activities that according to recent studies of neurobiology can cause serious brain disorders..

For this reason we have created Perygen an information platform aimed at athletes and doctors to create awareness about this problem, exchange information, data and useful experiences.

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25/09/2021

A small pilot study from the Mayo Clinic found signs of chronic traumatic encephalopathy in only one in 10 patients

Difficult-to-treat epilepsy could be an early sign of chronic traumatic encephalopathy (CTE), but it is a rare occurrence. This is what emerges from a small preliminary study published in the journal Neurology by a group of researchers at the Mayo Clinic in Rochester, Minnesota, led by Gregory D. Cascino.

For this pilot study, the researchers microscopically analyzed sections of brain tissue from 10 subjects with epilepsy for 24 years on average, who underwent extra-temporal cortical resection at age 33 on average, in order to check for attacks not fully controllable with drugs.

One of the participants showed the presence of scattered brain lesions caused by tangles of tau protein, considered signs of CTE. The same subject had suffered from seizures of epilepsy for 28 years prior to surgery and had a history of mild brain trauma caused by the seizures. In the remaining nine subjects, the researchers found no evidence of CTE.

"Previous studies have found signs of CTE in a quarter or even a third of elderly patients with epilepsy, so our study aimed to clarify whether these signs could also be found in younger epileptic subjects," explained the lead author of the work. “Our study suggests that tau accumulating in the brain is unlikely to contribute to cognitive impairment in young patients with epilepsy and localized seizures who do not respond to drug therapies; only one subject out of 10 analyzed showed signs of CTE: our sample was very limited, so further studies will be needed to confirm the results ”.

24/09/2021

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22/09/2021

Traumatic Brain Injury (TBI), also referred to as intracranial injuries or simply head injuries, occur when sudden trauma causes brain damage.

Brain trauma can result from a closed head injury or a penetrating head injury, and is one of two types of acquired brain injury. The other subtype is non-traumatic brain injury (e.g. stroke, meningitis, anoxia). Parts of the brain that can be damaged include the cerebral hemispheres, cerebellum, spinal cord (see brain damage).

Symptoms of TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. The outcome can range from complete recovery of all functions to permanent disability or death.

Head injuries are a major public health problem. The age groups most at risk are children aged 5 to 9 and the over 80s. Children up to 5 years of age are also at high risk for CT. Every year in the United States of America:

about 2 million people have CT (moderate to severe);
about 500,000 people are hospitalized for CT;
approximately 60,000 new cases of epilepsy occur as a result of head trauma;
about 50,000 people die from head injuries;
approximately 80,000 survive with chronic disabilities as a result of the injuries.

20/09/2021

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17/09/2021

Larry, like many of his former colleagues, fights a tough battle against chronic traumatic encephalopathy, a pathological condition caused by the accumulation of cerebral concussions over time. "I discovered this syndrome by watching a 2015 film that dealt with the subject," he revealed. The film in question is "Game Brain", with Will Smith in the part of Dr. Bennet Omalu, the Nigerian neuropathologist who first discovered CTE and immediately started a battle against all those contact sports that do not give the right importance to health. athletes and do not take the necessary precautions.

"I don't want my daughter's earliest memories to be of a dad in trouble, with a degenerative brain disorder that makes him unable to love." Larry is only 38 years old and, although CTE can only be diagnosed after death, he is sure he is fighting a tiring war made up of headaches, mood swings, memory loss and even suicidal impulses: "I am hypersensitive to lights and sounds, I often can't stay in crowded places. I pass from states of happiness to moments of depression even within 15 minutes, so much so that in the past I have also resorted to “toxic” solutions to try to limit the alterations ». When the remedy becomes worse than the disease.

Six years in Kansas, then Cincinnati, Washington and Miami: Johnson, however, does not remember anything of two whole seasons. From the Federation there are still those who try to deny the correlation between football and the syndrome, but the analyzes on 111 deceased players' brains, reported in July by the Journal of the American Medical Association, leave little room for replies: as many as 110 (99% ) presented unambiguous signs. Holes as big as Gruyere and huge brown spots: the CTE for football is comparable to the ALS for football, pathologies that leave no way out. "Today, thanks to the love for my daughter, I finished with those behaviors that led me on the wrong path."

Unfortunately, however, there is still no cure to stop the advance of this ruthless disease.

16/09/2021

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10/09/2021

Aaron Hernandez, a former Patriots star who committed su***de in April at just 27, was suffering from brain degeneration, caused by too many blows to the head he received while playing football.

#2015

The family sued the league and its former franchise

The film Concussion, brought to success in 2015 by Will Smith, becomes reality. Former NFL star Aaron Hernandez, who committed su***de in mid-April last year while serving a life sentence for murder, suffered from brain degeneration, according to his brain tests that were released by the family's lawyer. The Boston University Chronic Traumatic Encephalopathy Center, which had taken charge of the case, confirmed the diagnosis after two in-depth examinations. According to what was communicated, Hernandez suffered from ETC of grade 3 on a scale of 4: these brain traumas were caused by the repeated and violent blows that American football players usually suffer.

This disease is also associated with depression and unpredictable, often violent behavior, as well as numerous su***des. It is no coincidence, then, that Hernandez hanged himself in his Massachusetts cell, where he was serving a life sentence after being convicted of first degree murder of an acquaintance. The former tigh end of the Patriots was awarded in 2013 as Inspiration to Youth Award by Pop Warner, or as a player to whom young players could be inspired. This was due to his work ethic, his professionalism and his talent, which had allowed him to win a title as a protagonist in 2009 in the NCAA with the Florida Gators.

09/09/2021

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06/09/2021

When he was on the baseball field, Ryan Freel was unafraid to fling his body, and his head, into plays -- diving after balls and crashing into outfield walls.
That fearlessness earned the undersized Freel a spot in the big leagues, as well as a raft of concussions.

Now, nearly a year after his death, Freel has the distinction of being the first Major League Baseball player to be diagnosed with chronic traumatic encephalopathy (CTE), according to researchers at the Boston University School of Medicine.

"The real important issue is that he hit his head multiple times -- small hits, big hits, in baseball and outside of baseball," said Robert Stern, co-founder of the Center for the Study of Traumatic Encephalopathy at BU.
"When it comes to the development of CTE, our current sense is that it requires repetitive brain trauma and not just a couple of big concussions."

Freel committed su***de last December at the age of 36.
Testing of his brain tissue after death -- the only way to definitively diagnose CTE -- found that he had Stage 2 CTE, which is associated with erratic behavior and memory loss. Stage 4, the worst possible expression of the disease, is associated with full-blown dementia, aggression and paranoia.

The brain tissue of people found to have CTE displays an abnormal build-up of tau -- a protein that, when it spills out of cells, can choke off, or disable, neural pathways controlling things like memory, judgment and fear.

Freel's stepfather Clark Vargas said on Sunday that the new diagnosis confirmed what he suspected already.

"It provides some solace that there is a reason now for Ryan having done what he did," Vargas said. "Knowing that he's been suffering for 11 years and that CTE is a progressive disease, it gives explanation (for) some of the irrational things that he may have done. You know, he had a reason."
The disease tends to be associated with bruising sports like football and hockey, where repetitive brain trauma is part of the game.

03/09/2021

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02/09/2021

Research funded by the Football Association shows that 11% of footballers die in a state of dementia, while the percentage in the rest of the population is 3%, given that it would be linked to injuries caused by head shots. Experts suggest abolishing them from youth football.

The data is alarming and according to the experts it deserves attention, or at least that we stop to wonder about the issue: former professional footballers are 3 and a half times more likely to suffer from dementia and other serious neurological diseases than the general population, and the cause would lie in the head shots that football contemplates. A “fundamental” - as it is called - taught since football school, to which children are therefore accustomed at an early age. Trauma most of the time "light", since it is "only" the impact with the ball, but still trauma, which in the case of brains still in the development phase can lead to serious damage, according to the researchers. The alarm, in fact, mainly concerns players under 18.

Eliminate the header?

Bennet Omalu, the neuropathologist who discovered chronic traumatic encephalopathy (CTE) in American football players and published the results, also inspiring a famous film ("Shadow Zone") with Will Smith, called it a "health problem. public ", absolutely not to be underestimated, but he is not surprised by the results. Although the precise cause of these diseases is still unknown and the health benefits of sport (including football) are undeniable, Omalu believes that children in particular should be protected and that common sense should lead to the abolition of aerial play in football. “There shouldn't be any header under the age of 18,” he explains. “Why 18? Because that's when the human brain fully develops. This is why it is not intelligent for a human being to use his head to stop or deflect a ball traveling at high speed ”. The FA, meanwhile, believes that there is insufficient evidence to eliminate the header from the Under18 football: but the alarm is raised.

#2015

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