03/16/2022
Let’s talk about exercise and type 2 diabetes.
This study was the first that made me realize just how powerful exercise is at preventing chronic disease. You can find the article here:
https://www.nejm.org/doi/full/10.1056/nejmoa012512
So, what’s going on in this graph? The authors assigned 3234 people with prediabetes to a placebo group, a metformin group, and a lifestyle modification group and followed them for an average of almost 3 years. What happened?
Unsurprisingly, more people in the placebo group developed diabetes than the metformin group or the lifestyle modification group. Metformin reduced the incidence of diabetes by 31%, lifestyle by 58%. To quote the authors “the lifestyle intervention was significantly more effective than metformin.”
I don’t know if you know anything about metformin, but as far as drugs go, it’s excellent. Want to know what the lifestyle intervention was? A 16-lesson curriculum encouraging participants to meet the minimum physical activity guidelines of 150 minutes of brisk walking per week and to achieve and maintain a weight reduction of 7% of initial body weight. Quite basic, really. And that was almost twice as effective as the best pharmaceutical available for the same outcome. Lifestyle beat metformin by about as much as metformin beat placebo. This is, to put it scientifically, bananas.
Think about what the results would be like if the lifestyle group added two strength training sessions per week 🤯