11/09/2019
What is creatine? Is it a safe supplement? what are the different forms of creatine?
Creatine is involved in energy metabolism processes primarily in tissues with high energy demand such as skeletal muscle, brain and heart. It is produced endogenously from the three amino acids: glycine, arginine and methionine. The synthesis starts primarily in the kidneys and is completed in the liver. The daily creatine production amounts to approximately 1 to 2 g, of which about 95 % are distributed to the muscle.
In addition, creatine is found mainly in meat, fish and other animal products. Such dietary sources estimated to contribute to a daily intake of about 2g. The total creatine pool is assumed to be 120-140 g, with a daily degradation to creatinine of about 2 g, which is released via the blood to the kidneys and urine.
Creatine monohydrate is the most popular and safest form of creatine supplements. Other creatine forms marketed creatine are claimed to improve physical and chemical properties, bioavailability, effectiveness and safety. While the safety of creatine monohydrate has been well investigated, information on other creatine forms is limited. In some cases, the precise chemical structure of these formulas, could not be clarified (e.g. creatine phosphate/ gluconate).
Safety concerns for some of the creatine forms:
- Creatine taurinate: when there is an additional intake of taurine via energy drinks or energy shots, the total daily taurine intake has to be taken into account for safety considerations.
- Creatine phosphate: gastrointestinal symptoms have been reported after supplementation of more than 750 mg phosphorus per day
- Tricreatine orotate: Significant safety concerns due to tumor-promoting effects of orotic acid
- Creatine ethyl ester: increase in creatinine levels in serum after intake of this creatine form probably due to high conversion of creatine ethyl ester to creatinine in the gastrointestinal tract..!!
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